Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Recombinant Human IL-6



Catalog Number : 200-06

Description

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Monkey, Mouse, Rat
 
Biological Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107units/mg.
 
AA Sequence
PVPPGEDSK DVAAPHRQP LTSSERIDK QIRYILDGI SALRKETCN KSNMCESSK EALAENNLN LPKMAEKDG CFQSGFNEE TCLVKIITG LLEFEVYLE YLQNRFESS EEQARAVQM STKVLIQFL QKKAKNLDA ITTPDPTTN ASLLTKLQA QNQWLQDMT THLILRSFK EFLQSSLRA LRQM
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research
Cell Type: B Cells, Monocytes and Macrophages, T Cells
Protein Cross Reactivity: Monkey, Mouse, Rat

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00