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Recombinant Human IL-36RA



Catalog Number : 200-36RA

Description

The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α, -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
 
AA Sequence
VLSGALCFR MKDSALKVL YLHNNQLLA GGLHAEKVI KGEEISVVP NRALDASLS PVILGVQGG SQCLSCGTE KGPILKLEP VNIMELYLG AKESKSFTF YRRDMGLTS SFESAAYPG WFLCTSPEA DQPVRLTQI PEDPAWDAP ITDFYFQQC D
Research Interest: Innate Immunity, Immunology, Cancer, Neurosciences, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Cell Type: Dendritic Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00