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Recombinant Human IL-36γ (IL-1F9)



Catalog Number : 200-36G

Description

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to induce IL-8 production by human PBMCs.
 
AA Sequence
SMCKPITGT INDLNQQVW TLQGQNLVA VPRSDSVTP VTVAVITCK YPEALEQGR GDPIYLGIQ NPEMCLYCE KVGEQPTLQ LKEQKIMDL YGQPEPVKP FLFYRAKTG RTSTLESVA FPDWFIASS KRDQPIILT SELGKSYNT AFELNIND
Research Interest: Innate Immunity, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Cell Type: Dendritic Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00