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Recombinant Human IL-31



Catalog Number : 200-31

Description

Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to induce STAT3 activation in human U87 cells.
 
AA Sequence
SHTLPVRLL RPSDDVQKI VEELQSLSK MLLKDVEEE KGVLVSQNY TLPCLSPDA QPPNNIHSP AIRAYLKTI RQLDNKSVI DEIIEHLDK LIFQDAPET NISVPTDTH ECKRFILTI SQQFSECMD LALKSLTSG AQQATT
Research Interest: Innate Immunity, Adaptive Immunity, Inflammation
Cell Type: T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00