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Recombinant Human IL-1β



Catalog Number : 200-01B

Description

IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Frog, Monkey, Mouse, Rabbit, Rat, Sheep
 
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ≤ 1.0 pg/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
 
AA Sequence
APVRSLNCT LRDSQQKSL VMSGPYELK ALHLQGQDM EQQVVFSMS FVQGEESND KIPVALGLK EKNLYLSCV LKDDKPTLQ LESVDPKNY PKKKMEKRF VFNKIEINN KLEFESAQF PNWYISTSQ AENMPVFLG GTKGGQDIT DFTMQFVSS
Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Cell Type: B Cells, Monocytes and Macrophages
Protein Cross Reactivity: Frog, Monkey, Mouse, Rabbit, Rat, Sheep

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00