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Recombinant Human IL-17 (IL-17A)



Catalog Number : 200-17

Description

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.  Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.  The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.  IL-17A exhibits cross-species bioactivity between human and murine cells.  Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Assay #1: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml.
Assay #2: Measured by its ability to
 
AA Sequence
MIVKAGITI PRNPGCPNS EDKNFPRTV MVNLNIHNR NTNTNPKRS SDYYNRSTS PWNLHRNED PERYPSVIW EAKCRHLGC INADGNVDY HMNSVPIQQ EILVLRREP PHCPNSFRL EKILVSVGC TCVTPIVHH VA
Research Interest: Adaptive Immunity, Immunology, Angiogenesis, Inflammation
Cell Type: T Cells, Treg cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00