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Recombinant Human IL-12



Catalog Number : 200-12

Description

IL-12 is a potent regulator of cell mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Additional Information

Source:
CHO cells
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Bacteria, Monkey, Mouse
 
Biological Activity
The ED50 was determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
AA Sequence

p35 Subunit:< /B>RNLPVA TPDPGMFPC LHHSQNLLR AVSNMLQKA RQTLEFYPC TSEEIDHED ITKDKTSTV EACLPLELT KNESCLNSR ETSFITNGS CLASRKTSF MMALCLSSI YEDLKMYQV EFKTMNAKL LMDPKRQIF LDQNMLAVI DELMQALNF NSETVPQKS SLEEPDFYK TKIKLCILL HAFRIRAVT IDRVMSYLN AS

p 40Subunit :IWEL KKDVYVVEL DWYPDAPGE MVVLTCDTP EEDGITWTL DQSSEVLGS GKTLTIQVK EFGDAGQYT CHKGGEVLS HSLLLLHKK EDGIWSTDI LKDQKEPKN KTFLRCEAK NYSGRFTCW WLTTISTDL TFSVKSSRG SSDPQGVTC GAATLSAER VRGDNKEYE YSVECQEDS ACPAAEESL PIEVMVDAV HKLKYENYT SSFFIRDII KPDPPKNLQ LKPLKNSRQ VEVSWEYPD TWSTPHSYF SLTFCVQVQ GKSKREKKD RVFTDKTSA TVICRKNAS ISVRAQDRY YSSSWSEWA SVPCS

Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Inflammation
Cell Type: Monocytes and Macrophages, NK and NKT Cells, T Cells, Dendritic Cells
Protein Cross Reactivity: Bacteria, Monkey, Mouse

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,560.00
500µg
$4,680.00
1mg
$7,800.00