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Recombinant Human IL-12 p80



Catalog Number : 200-12p80H

Description

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Additional Information

Source:
(BTI-Tn-5B1-4) Hi-5 Insect cells*
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Not available.
 
AA Sequence
p40sub unit: IWELKKDVY VVELDWYPD APGEMVVLT CDTPEEDGI TWTLDQSSE VLGSGKTLT IQVKEFGDA GQYTCHKGG EVLSHSLLL LHKKEDGIW STDILKDQK EPKNKTFLR CEAKNYSGR FTCWWLTTI STDLTFSVK SSRGSSDPQ GVTCGAATL SAERVRGDN KEYEYSVEC QEDSACPAA EESLPIEVM VDAVHKLKY ENYTSSFFI RDIIKPDPP KNLQLKPLK NSRQVEVSW EYPDTWSTP HSYFSLTFC VQVQGKSKR EKKDRVFTD KTSATVICR KNASISVRA QDRYYSSSW SEWASVPCS
Research Interest: Innate Immunity, Inflammation
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,560.00
500µg
$4,680.00
1mg
$7,800.00