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Recombinant Human IL-10



Catalog Number : 200-10

Description

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Bacteria, Monkey, Mouse, Virus
 
Biological Activity
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
 
AA Sequence
MSPGQGTQS ENSCTHFPG NLPNMLRDL RDAFSRVKT FFQMKDQLD NLLLKESLL EDFKGYLGC QALSEMIQF YLEEVMPQA ENQDPDIKA HVNSLGENL KTLRLRLRR CHRFLPCEN KSKAVEQVK NAFNKLQEK GIYKAMSEF DIFINYIEA YMTMKIRN
Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation
Cell Type: B Cells, Monocytes and Macrophages, T Cells, Treg cells
Protein Cross Reactivity: Bacteria, Monkey, Mouse, Virus

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00