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Recombinant Human IL-1α



Catalog Number : 200-01A

Description

IL-1α is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Cow, Monkey, Mouse
 
Biological Activity
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
 
AA Sequence
SAPFSFLSN VKYNFMRII KYEFILNDA LNQSIIRAN DQYLTAAAL HNLDEAVKF DMGAYKSSK DDAKITVIL RISKTQLYV TAQDEDQPV LLKEMPEIP KTITGSETN LLFFWETHG TKNYFTSVA HPNLFIATK QDYWVCLAG GPPSITDFQ ILENQA
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Cell Type: B Cells, Monocytes and Macrophages
Protein Cross Reactivity: Cow, Monkey, Mouse

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00