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Recombinant Human IGF-II



Catalog Number : 100-12

Description

The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse, Rat, Tiger Salamander
 
Biological Activity
The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
 
AA Sequence
AYRPSETLC GGELVDTLQ FVCGDRGFY FSRPASRVS RRSRGIVEE CCFRSCDLA LLETYCATP AKSE
Research Interest: Angiogenesis, Bone Biology, Inflammation, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Protein Cross Reactivity: Mouse, Rat, Tiger Salamander

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$280.00
500µg
$840.00
1mg
$1,400.00