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Recombinant Human IGF-BP3



Catalog Number : 100-08

Description

IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
 
AA Sequence
GASSGGLGP VVRCEPCDA RALAQCAPP PAVCAELVR EPGCGCCLT CALSEGQPC GIYTERCGS GLRCQPSPD EARPLQALL DGRGLCVNA SAVSRLRAY LLPAPPAPG NASESEEDR SAGEVESPS VSSTHRVSD PKFHPLHSK IIIIKKGHA KDSQRYKVD YESQSTDTQ NFSSESKRE TEYGPCRRE MEDTLNHLK FLNVLSPRG VHIPNCDKK GFYKKKQCR PSKGRKRGF CWCVDKYGQ PLPGYTTKG KEDVHCYSM QSK
Research Interest: Apoptosis, Cancer, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00