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Recombinant Human IGF-BP1



Catalog Number : 350-10

Description

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
The ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is ≤ 0.5 μg/ml in the presence of 6 ng/ml of human IGF-I.
 
AA Sequence
MAPWQCAPC SAEKLALCP PVSASCSEV TRSAGCGCC PMCALPLGA ACGVATARC ARGLSCRAL PGEQQPLHA LTRGQGACV QESDASAPH AAEAGSPES PESTEITEE ELLDNFHLM APSEEDHSI LWDAISTYD GSKALHVTN IKKWKEPCR IELYRVVES LAKAQETSG EEISKFYLP NCNKNGFYH SRQCETSMD GEAGLCWCV YPWNGKRIP GSPEIRGDP NCQIYFNVQ N
Research Interest: Apoptosis, Cancer, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$120.00
25µg
$250.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00