Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Recombinant Human IFN-γ



Catalog Number : 300-02

Description

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Monkey
 
Biological Activity
Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml.
Assay #2: The ED50 was determined by a cytotoxicity assay using HT-29
 
AA Sequence
MQDPYVKEA ENLKKYFNA GHSDVADNG TLFLGILKN WKEESDRKI MQSQIVSFY FKLFKNFKD DQSIQKSVE TIKEDMNVK FFNSNKKKR DDFEKLTNY SVTDLNVQR KAIHELIQV MAELSPAAK TGKRKRSQM LFQGRRASQ
Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Metabolic Regulation and Diabetes
Cell Type: B Cells, Monocytes and Macrophages, NK and NKT Cells, Treg cells
Protein Cross Reactivity: Monkey

Availability: In stock

Size Price Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00