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Recombinant Human ICAM-1



Catalog Number : 150-05

Description

ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.

Additional Information

Source:
CHO cells
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Bacteria
 
Biological Activity
ICAM-1 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25μg/ml ICAM-1 concentration.
 
AA Sequence
QTSVSPSKV ILPRGGSVL VTCSTSCDQ PKLLGIETP LPKKELLLP GNNRKVYEL SNVQEDSQP MCYSNCPDG QSTAKTFLT VYWTPERVE LAPLPSWQP VGKNLTLRC QVEGGAPRA NLTVVLLRG EKELKREPA VGEPAEVTT TVLVRRDHH GANFSCRTE LDLRPQGLE LFENTSAPY QLQTFVLPA TPPQLVSPR VLEVDTQGT VVCSLDGLF PVSEAQVHL ALGDQRLNP TVTYGNDSF SAKASVSVT AEDEGTQRL TCAVILGNQ SQETLQTVT IYSFPAPNV ILTKPEVSE GTEVTVKCE AHPRAKVTL NGVPAQPLG PRAQLLLKA TPEDNGRSF SCSATLEVA GQLIHKNQT RELRVLYGP RLDERDCPG NWTWPENSQ QTPMCQAWG NPLPELKCL KDGTFPLPI GESVTVTRD LEGTYLCRA RSTQGEVTR KVTVNVLSP RYE
Research Interest: Angiogenesis, Inflammation
Cell Type: Endothelial Cells
Protein Cross Reactivity: Bacteria

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00