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Recombinant Human HGF



Catalog Number : 100-39

Description

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.*Manufactured using (BTI-Tn-5B1-4) cells under license from Boyce Thompson Institute for Plant Research, Inc.

Additional Information

Source:
(BTI-Tn-5B1-4) Hi-5 Insect cells*
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Dog, Monkey, Mouse, Rabbit, Rat, Human + Mouse
 
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells was found to be in the range of 20.0-40.0 ng/ml.
 
AA Sequence

alp hachain:< /B>QRKRRN TIHEFKKSA KTTLIKIDP ALKIKTKKV NTADQCANR CTRNKGLPF TCKAFVFDK ARKQCLWFP FNSMSSGVK KEFGHEFDL YENKDYIRN CIIGKGRSY KGTVSITKS GIKCQPWSS MIPHEHSFL PSSYRGKDL QENYCRNPR GEEGGPWCF TSNPEVRYE VCDIPQCSE VECMTCNGE SYRGLMDHT ESGKICQRW DHQTPHRHK FLPERYPDK GFDDNYCRN PDGQPRPWC YTLDPHTRW EYCAIKTCA DNTMNDTDV PLETTECIQ GQGEGYRGT VNTIWNGIP CQRWDSQYP HEHDMTPEN FKCKDLREN YCRNPDGSE SPWCFTTDP NIRVGYCSQ IPNCDMSHG QDCYRGNGK NYMGNLSQT RSGLTCSMW DKNMEDLHR HIFWEPDAS KLNENYCRN PDDDAHGPW CYTGNPLIP WDYCPISRC EGDTTPTIV NLDHPVISC AKTKQLR

b etachain: VVNGI PTRTNIGWM VSLRYRNKH ICGGSLIKE SWVLTARQC FPSRDLKDY EAWLGIHDV HGRGDEKCK QVLNVSQLV YGPEGSDLV LMKLARPAV LDDFVSTID LPNYGCTIP EKTSCSVYG WGYTGLINY DGLLRVAHL YIMGNEKCS QHHRGKVTL NESEICAGA EKIGSGPCE GDYGGPLVC EQHKMRMVL GVIVPGRGC AIPNRPGIF VRVAYYAKW IHKIILTYK VPQS

Research Interest: Stem Cell Research, Cancer, Angiogenesis, Neurosciences, Proliferation and Cell Cycle
Protein Cross Reactivity: Dog, Monkey, Mouse, Rabbit, Rat, Human + Mouse

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$960.00
500µg
$2,800.00
1mg
$4,800.00