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Recombinant Human GDF-5 (BMP-14/CDMP-1)



Catalog Number : 120-01

Description

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 354 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids. License: This product is produced solely by PeproTech Inc. under a license from Biopharm GmbH, Germany. Biopharm GmbH is not responsible for the quality or fitness for use of this product. It may be used only for research purposes and may neither be used in humans nor for veterinary purposes. This product may not be used for commercial purposes.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
 
AA Sequence
APSATRQGK RPSKNLKAR CSRKALHVN FKAPSATRQ GKRPSKNLK ARCSRKALH VNFKDMGWD DMGWDDWII APLEYEAFH CEGLCEFPL RSHLEPTNH AVIQTLMNS MDPESTPPT CCVPTRLSP ISILFIDSA NNVVYKQYE DMVVESCGC R
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00