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Recombinant Human GDF-3



Catalog Number : 120-22

Description

GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
 
AA Sequence
AAIPVPKLS CKNLCHRHQ LFINFRDLG WHKWIIAPK GFMANYCHG ECPFSLTIS LNSSNYAFM QALMHAVDP EIPQAVCIP TKLSPISML YQDNNDNVI LRHYEDMVV DECGCG
Research Interest: Stem Cell Research, Metabolic Regulation and Diabetes
Cell Type: Stem Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00