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Recombinant Human GDF-11



Catalog Number : 120-11

Description

GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml.
 
AA Sequence
NLGLDCDEH SSESRCCRY PLTVDFEAF GWDWIIAPK RYKANYCSG QCEYMFMQK YPHTHLVQQ ANPRGSAGP CCTPTKMSP INMLYFNDK QQIIYGKIP GMVVDRCGC S
Research Interest: Stem Cell Research, Neurosciences
Cell Type: Neurons
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00