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Recombinant Human GASP-1



Catalog Number : 120-41

Description

Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.

Additional Information

Source:
CHO cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to inhibit human Myostatin (GDF-8) activity in MCP-11 cells.  The ED50 for this effect is 0.0025-0.0040 µg/ml in the presence of 5ng/ml of human Myostatin (GDF-8).
 
AA Sequence
LPPIRYSHA GICPNDMNP NLWVDAQST CRRECETDQ ECETYEKCC PNVCGTKSC VAARYMDVK GKKGPVGMP KEATCDHFM CLQQGSECD IWDGQPVCK CKDRCEKEP SFTCASDGL TYYNRCYMD AEACSKGIT LAVVTCRYH FTWPNTSPP PPETTMHPT TASPETPEL DMAAPALLN NPVHQSVTM GETVSFLCD VVGRPRPEI TWEKQLEDR ENVVMRPNH VRGNVVVTN IAQLVIYNA QLQDAGIYT CTARNVAGV LRADFPLSV VRGHQAAAT SESSPNGTA FPAAECLKP PDSEDCGEE QTRWHFDAQ ANNCLTFTF GHCHRNLNH FETYEACML ACMSGPLAA CSLPALQGP CKAYAPRWA YNSQTGQCQ SFVYGGCEG NGNNFESRE ACEESCPFP RGNQRCRAC KPRQKLVTS FCRSDFVIL GRVSELTEE PDSGRALVT VDEVLKDEK MGLKFLGQE PLEVTLLHV DWACPCPNV TVSEMPLII MGEVDGGMA MLRPDSFVG ASSARRVRK LREVMHKKT CDVLKEFLG LH
Research Interest: Stem Cell Research, Angiogenesis, Bone Biology, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$750.00
500µg
$2,340.00
1mg
$3,900.00