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Recombinant Human Galectin-3



Catalog Number : 450-38

Description

Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-3 regulates a number of biological processes, including embryogenesis, inflammatory responses, cell progression and metastasis. Galectin-3 is normally expressed in epithelia of a variety of tissues, including colon and endometrium, and in various inflammatory cells, including macrophages. Galectin-3 can function intracellularly, in controlling cell cycle and preventing T-cell apoptosis, and also extracellularly, in activating various cells, including monocytes/macrophages, mast cells, neutrophils, and lymphocytes. Expression of Galectin-3 is affected by neoplastic transformation, being up-regulated in certain types of lymphomas, and in thyroid and hepatic carcinomas. Conversely, it is down-regulated in other cancers, such as colon, breast, ovarian, and uterine. Recombinant human Galectin-3 is a globular 26.0kDa protein containing 250 amino acid residues, but no disulfide bonds.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 µg/ml with a peak response obtained at 250 µg/ml.
 
AA Sequence
ADNFSLHDA LSGSGNPNP QGWPGAWGN QPAGAGGYP GASYPGAYP GQAPPGAYP GQAPPGAYH GAPGAYPGA PAPGVYPGP PSGPGAYPS SGQPSAPGA YPATGPYGA PAGPLIVPY NLPLPGGVV PRMLITILG TVKPNANRI ALDFQRGND VAFHFNPRF NENNRRVIV CNTKLDNNW GREERQSVF PFESGKPFK IQVLVEPDH FKVAVNDAH LLQYNHRVK KLNEISKLG ISGDIDLTS ASYTMI
Research Interest: Innate Immunity, Immunology, Cancer, Inflammation, Proliferation and Cell Cycle
Cell Type: Monocytes and Macrophages, T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00