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Recombinant Human Follistatin



Catalog Number : 120-13

Description

Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Mouse
 
Biological Activity
Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.
 
AA Sequence
GNCWLRQAK NGRCQVLYK TELSKEECC STGRLSTSW TEEDVNDNT LFKWMIFNG GAPNCIPCK ETCENVDCG PGKKCRMNK KNKPRCVCA PDCSNITWK GPVCGLDGK TYRNECALL KARCKEQPE LEVQYQGRC KKTCRDVFC PGSSTCVVD QTNNAYCVT CNRICPEPA SSEQYLCGN DGVTYSSAC HLRKATCLL GRSIGLAYE GKCIKAKSC EDIQCTGGK KCLWDFKVG RGRCSLCDE LCPDSKSDE PVCASDNAT YASECAMKE AACSSGVLL EVKHSGSCN
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Protein Cross Reactivity: Chicken, Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$850.00
500µg
$3,120.00
1mg
$5,200.00