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Recombinant Human EGF Receptor (EGFR)



Catalog Number : 100-15R

Description

EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HB-EGF, Betacellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.

Additional Information

Source:
CHO cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Testing in progress.
 
AA Sequence
LEEKKVCQG TSNKLTQLG TFEDHFLSL QRMFNNCEV VLGNLEITY VQRNYDLSF LKTIQEVAG YVLIALNTV ERIPLENLQ IIRGNMYYE NSYALAVLS NYDANKTGL KELPMRNLQ EILHGAVRF SNNPALCNV ESIQWRDIV SSDFLSNMS MDFQNHLGS CQKCDPSCP NGSCWGAGE ENCQKLTKI ICAQQCSGR CRGKSPSDC CHNQCAAGC TGPRESDCL VCRKFRDEA TCKDTCPPL MLYNPTTYQ MDVNPEGKY SFGATCVKK CPRNYVVTD HGSCVRACG ADSYEMEED GVRKCKKCE GPCRKVCNG IGIGEFKDS LSINATNIK HFKNCTSIS GDLHILPVA FRGDSFTHT PPLDPQELD ILKTVKEIT GFLLIQAWP ENRTDLHAF ENLEIIRGR TKQHGQFSL AVVSLNITS LGLRSLKEI SDGDVIISG NKNLCYANT INWKKLFGT SGQKTKIIS NRGENSCKA TGQVCHALC SPEGCWGPE PRDCVSCRN VSRGRECVD KCNLLEGEP REFVENSEC IQCHPECLP QAMNITCTG RGPDNCIQC AHYIDGPHC VKTCPAGVM GENNTLVWK YADAGHVCH LCHPNCTYG CTGPGLEGC PTNGPKIPS
Research Interest: Stem Cell Research, Cancer, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00