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Recombinant Human E-Selectin



Catalog Number : 150-15

Description

Selectins are a family of calcium-dependent type 1 transmembrane proteins. Endothelial (E)-selectin is a heavily glycosylated transmembrane protein expressed by activated endothelial cells in microvascular linings. E-selectin, along with P-selectin and L-selectin, initiate recruitment of circulating leukocytes from blood to sites of inflammation in the vascular lining through interaction with specific cell surface associated carbohydrate determinants. E-selectin consists of an N-terminal type 1 lectin domain, an EGF-like domain, 6 sushi (CCP/SCR) domains, a transmembrane sequence, and a short cytoplasmic domain. Recombinant human E-selectin is a 58.6 kDa protein containing 535 amino acid residues, corresponding to the extracellular portion of the full length protein. Due to glycosylation, E-selectin migrates at an apparent molecular weight of approximately 65-85 kDa by SDS-PAGE analysis under reducing conditions.

Additional Information

Source:
CHO cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to support adhesion of U937 cells, a human hystiocytic lymphoma cell line.
 
AA Sequence
WSYNTSTEA MTYDEASAY CQQRYTHLV AIQNKEEIE YLNSILSYS PSYYWIGIR KVNNVWVWV GTQKPLTEE AKNWAPGEP NNRQKDEDC VEIYIKREK DVGMWNDER CSKKKLALC YTAACTNTS CSGHGECVE TINNYTCKC DPGFSGLKC EQIVNCTAL ESPEHGSLV CSHPLGNFS YNSSCSISC DRGYLPSSM ETMQCMSSG EWSAPIPAC NVVECDAVT NPANGFVEC FQNPGSFPW NTTCTFDCE EGFELMGAQ SLQCTSSGN WDNEKPTCK AVTCRAVRQ PQNGSVRCS HSPAGEFTF KSSCNFTCE EGFMLQGPA QVECTTQGQ WTQQIPVCE AFQCTALSN PERGYMNCL PSASGSFRY GSSCEFSCE QGFVLKGSK RLQCGPTGE WDNEKPTCE AVRCDAVHQ PPKGLVRCA HSPIGEFTY KSSCAFSCE EGFELHGST QLECTSQGQ WTEEVPSCQ VVKCSSLAV PGKINMSCS GEPVFGTVC KFACPEGWT LNGSAARTC GATGHWSGL LPTCEAPTE SNIP
Research Interest: Angiogenesis, Inflammation
Cell Type: Endothelial Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00