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Animal-Free Recombinant Human BMP-2



Catalog Number : AF-120-02

Description

BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.  Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Cow, Dog, Monkey, Mouse, Rabbit, Rat
 
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
 
AA Sequence
MQAKHKQRK RLKSSCKRH PLYVDFSDV GWNDWIVAP PGYHAFYCH GECPFPLAD HLNSTNHAI VQTLVNSVN SKIPKACCV PTELSAISM LYLDENEKV VLKNYQDMV VEGCGCR
Research Interest: Stem Cell Research, Angiogenesis, Bone Biology, Proliferation and Cell Cycle
Protein Cross Reactivity: Cow, Dog, Monkey, Mouse, Rabbit, Rat

Availability: In stock

Size Price Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00