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Recombinant Human Artemin



Catalog Number : 450-17

Description

Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, Persephin and Neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRα (α1-α4) receptors. Artemin prefers the receptor GFRα3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia such as sympathetic, neural crest and placodally derived sensory neurons, and dompaminergic midbrain neurons. The functional human Artemin ligand is a disulfide-linked homodimer, of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Recombinant human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse, Rat
 
Biological Activity
Determined by it's ability to promote survival and neurite outgrowth and dorsal root ganglion neurons.
 
AA Sequence
AGGPGSRAR AAGARGCRL RSQLVPVRA LGLGHRSDE LVRFRFCSG SCRRARSPH DLSLASLLG AGALRPPPG SRPVSQPCC RPTRYEAVS FMDVNSTWR TVDRLSATA CGCLG
Research Interest: Neurosciences
Cell Type: Neurons
Protein Cross Reactivity: Mouse, Rat

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00