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Recombinant Human APRIL



Catalog Number : 310-10C

Description

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.

*Human APRIL(Catalog Number 310-10C) has replaced Human APRIL(Catalog Number 310-10)

Additional Information

Source:
Hi-5 Insect cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to induce cell death in Jurkat cells.
 
AA Sequence
AVLTQKQKK QHSVLHLVP INATSKDDS DVTEVMWQP ALRRGRGLQ AQGYGVRIQ DAGVYLLYS QVLFQDVTF TMGQVVSRE GQGRQETLF RCIRSMPSH PDRAYNSCY SAGVFHLHQ GDILSVIIP RARAKLNLS PHGTFLGFV KL
Research Interest: Adaptive Immunity, Apoptosis, Immunology, Cancer
Cell Type: B Cells, Monocytes and Macrophages, T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00