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Recombinant Human ApoE2



Catalog Number : 350-12

Description

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels. Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 90% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Data not available.
 
AA Sequence
MKVEQAVET EPEPELRQQ TEWQSGQRW ELALGRFWD YLRWVQTLS EQVQEELLS SQVTQELRA LMDETMKEL KAYKSELEE QLTPVAEET RARLSKELQ AAQARLGAD MEDVCGRLV QYRGEVQAM LGQSTEELR VRLASHLRK LRKRLLRDA DDLQKCLAV YQAGAREGA ERGLSAIRE RLGPLVEQG RVRAATVGS LAGQPLQER AQAWGERLR ARMEEMGSR TRDRLDEVK EQVAEVRAK LEEQAQQIR LQAEAFQAR LKSWFEPLV EDMQRQWAG LVEKVQAAV GTSAAPVPS DNH
Research Interest: Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
100µg
$80.00
500µg
$195.00
1mg
$350.00