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Recombinant Human ApoA-I



Catalog Number : 350-11

Description

ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high-density lipoprotein (HDL) particle. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This apoA-I ability enables HDL to remove excess peripheral cholesterol and return it to the liver for recycling and excretion. This process, called reverse cholesterol transport, is though to inhibit atherogenesis. For this reason HDL is also known as the “good cholesterol.” The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I (called apoA-I Milano). The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. Recombinant human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Hamster
 
Biological Activity
Data Not Available.
 
AA Sequence
MDEPPQSPW DRVKDLATV YVDVLKDSG RDYVSQFEG SALGKQLNL KLLDNWDSV TSTFSKLRE QLGPVTQEF WDNLEKETE GLRQEMSKD LEEVKAKVQ PYLDDFQKK WQEEMELYR QKVEPLRAE LQEGARQKL HELQEKLSP LGEEMRDRA RAHVDALRT HLAPYSDEL RQRLAARLE ALKENGGAR LAEYHAKAT EHLSTLSEK AKPALEDLR QGLLPVLES FKVSFLSAL EEYTKKLNT Q
Research Interest: Angiogenesis, Metabolic Regulation and Diabetes
Protein Cross Reactivity: Hamster

Availability: In stock

Size Price Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00