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Recombinant Human Apo-SAA



Catalog Number : 300-13

Description

Human apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apo-lipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human apo-SAA1α except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71(the latter two substituted residues are present in apo-SAA2β).

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Bacteria, Hamster, Mouse, Rabbit, Rat
 
Biological Activity
Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.*

* Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13
 
AA Sequence
MRSFFSFLG EAFDGARDM WRAYSDMRE ANYIGSDKY FHARGNYDA AKRGPGGVW AAEAISNAR ENIQRFFGR GAEDSLADQ AANEWGRSG KDPNHFRPA GLPEKY
Research Interest: Inflammation, Metabolic Regulation and Diabetes
Protein Cross Reactivity: Bacteria, Hamster, Mouse, Rabbit, Rat

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
1mg
$800.00