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Recombinant Human ANGPTL-3



Catalog Number : 130-18

Description

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind alpha-5/beta-3 integrins leading to endothelial cell adhesion and migration.  Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 62 kDa, and contains 452 amino acid residues including a C-terminal His tag.

Additional Information

Source:
CHO cells
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its binding ability to recombinant αvβ3 integrin in a functional ELISA. 
 
AA Sequence
SRIDQDNSS FDSLSPEPK SRFAMLDDV KILANGLLQ LGHGLKDFV HKTKGQIND IFQKLNIFD QSFYDLSLQ TSEIKEEEK ELRRTTYKL QVKNEEVKN MSLELNSKL ESLLEEKIL LQQKVKYLE EQLTNLIQN QPETPEHPE VTSLKTFVE KQDNSIKDL LQTVEDQYK QLNQQHSQI KEIENQLRR TSIQEPTEI SLSSKPRAP RTTPFLQLN EIRNVKHDG IPAECTTIY NRGEHTSGM YAIRPSNSQ VFHVYCDVI SGSPWTLIQ HRIDGSQNF NETWENYKY GFGRLDGEF WLGLEKIYS IVKQSNYVL RIELEDWKD NKHYIEYSF YLGNHETNY TLHLVAITG NVPNAIPEN KDLVFSTWD HKAKGHFNC PEGYSGGWW WHDECGENN LNGKYNKPR AKSKPERRR GLSWKSQNG RLYSIKSTK MLIHPTDSE SFEHHHHHH HH
Research Interest: Angiogenesis, Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00