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Recombinant Human Amphiregulin



Catalog Number : 100-55B

Description

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
 
AA Sequence
SVRVEQVVK PPQNKTESE NTSDKPKRK KKGGKNGKN RRNRKKKNP CNAEFQNFC IHGECKYIE HLEAVTCKC QQEYFGERC GEKSMKTHS MIDSSLSK
Research Interest: Cancer, Angiogenesis, Neurosciences, Bone Biology, Inflammation
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00