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Recombinant Human Adiponectin



Catalog Number : 450-24

Description

Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions.

Additional Information

Source:
Hi-5 Insect cells
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 3.0-6.0 μg/ml.
 
AA Sequence
RGHHHHHHH HETTTQGPG VLLPLPKGA CTGWMAGIP GHPGHNGAP GRDGRDGTP GEKGEKGDP GLIGPKGDI GETGVPGAE GPRGFPGIQ GRKGEPGEG AYVYRSAFS VGLETYVTI PNMPIRFTK IFYNQQNHY DGSTGKFHC NIPGLYYFA YHITVYMKD VKVSLFKKD KAMLFTYDQ YQENNVDQA SGSVLLHLE VGDQVWLQV YGEGERNGL YADNDNDST FTGFLLYHD TN
Research Interest: Inflammation, Metabolic Regulation and Diabetes
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$700.00
500µg
$3,120.00
1mg
$5,200.00