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Recombinant Human 4-1BB Ligand



Catalog Number : 310-11

Description

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml.
 Please Note: Results may vary with PBMC donors.
 
AA Sequence
MREGPELSP DDPAGLLDL RQGMFAQLV AQNVLLIDG PLSWYSDPG LAGVSLTGG LSYKEDTKE LVVAKAGVY YVFFQLELR RVVAGEGSG SVSLALHLQ PLRSAAGAA ALALTVDLP PASSEARNS AFGFQGRLL HLSAGQRLG VHLHTEARA RHAWQLTQG ATVLGLFRV TPEIPAGLP SPRSE
Research Interest: Adaptive Immunity, Immunology, Angiogenesis
Cell Type: T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00