Q-VD-OPH
Catalog Number : 1139855
description
Q-VD-OPH is a irreversible cell permeable broad spectrum caspace inhibitor. It is a more effective and less cytotoxic apoptosis inhibitor than Z-VAD-FMK and BOC-D-FMK. It is reported to prevent apoptosis mediated by the caspace 8/10, caspace 9/3, caspace 12 pathways.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
Q-Val-Asp(monomethylated)-Oph, Q-VD-(Ome)-OPH, quinoline-val-asp(OMe)-CH2-OPH
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
(3S)-5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid
|
|
Molecular Formula:
|
C26H25F2N3O6 |
|
Molecular Weight: |
513.5
|
|
CAS Number
|
1135695-98-5
|
|
Purity:
|
≥95%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Caserta, T. M., Smith, A. N., Gultice, A. D., Reedy, M. A., & Brown, T. L. (2003). Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis, 8(4), 345-352. Antar, V., Akdemir, O., Sağmanligil, A., Sahan, E., Çelik, Ö., Çolak, A., & Karaoğlan, A. (2009). Q-VD-OPh, a pancaspase inhibitor, reduces trauma-induced apoptosis and improves the recovery of hind-limb function in rats after spinal cord injury. Neurocirugía, 20(6), 533-540. Kuželová, K., Grebeňová, D., & Brodská, B. (2011). Dose‐dependent effects of the caspase inhibitor Q‐VD‐OPh on different apoptosis‐related processes.Journal of cellular biochemistry, 112(11), 3334-3342. |