Purmorphamine
Catalog Number : 4831086
description
Purmorphamine is an activator of the Smoothened protein in the hedgehog signaling pathway. It is reported to induce osteogenesis and influence the differentiation and growth of neurons.
Additional Information
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Applications:
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FA
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Synonyms:
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UNII-PB12M2F8KY, Shh Signaling Antagonist VI
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Formulation:
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Crystalline solid
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Chemical Name:
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9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine
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Molecular Formula:
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C31H32N6O2 |
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Molecular Weight: |
520.6
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CAS Number
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483367-10-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Wu, X., Walker, J., Zhang, J., Ding, S., & Schultz, P. G. (2004). Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chemistry & biology, 11(9), 1229-1238. Beloti, M. M., Bellesini, L. S., & Rosa, A. L. (2005). Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell biology international, 29(7), 537-541. Oliveira, F. S., Bellesini, L. S., Defino, H. L. A., da Silva Herrero, C. F., Beloti, M. M., & Rosa, A. L. (2012). Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells. Journal of cellular biochemistry, 113(1), 204-208. |