Phorbol 12-myristate 13-acetate (PMA)
Catalog Number : 1652981
description
Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
Additional Information
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Applications:
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FA
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Synonyms:
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PMA, TPA, Phorbol ester, croton oil.
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Formulation:
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Crystalline solid
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Chemical Name:
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12-O-Tetradecanoylphorbol-13-acetate
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Molecular Formula:
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C36H56O8 |
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Molecular Weight: |
616.8
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CAS Number
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16561-29-8
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Emerit, I., & Cerutti, P. A. (1981). Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action. Holtmann, H. E. L. M. U. T., & Wallach, D. A. V. I. D. (1987). Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. The Journal of Immunology, 139(4), 1161-1167. Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G., ... & June, C. H. (1989). CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences, 86(4), 1333-1337. |