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Phorbol 12-myristate 13-acetate (PMA)



Catalog Number : 1652981

Description

Phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol and activates the signal transduction enzyme protein kinase C (PKC). It is used as a tumor promoter and to stimulate division of B-cells. With ionomycin, PMA induces the activation of many cell types to produce cytokines.
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Additional Information

Applications:
FA
Synonyms:
PMA, TPA, Phorbol ester, croton oil.
Formulation:
Crystalline solid
Chemical Name:
12-O-Tetradecanoylphorbol-13-acetate
Molecular Formula:

C36H56O8

Molecular Weight:
616.8
CAS Number
16561-29-8
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Emerit, I., & Cerutti, P. A. (1981). Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action.

Holtmann, H. E. L. M. U. T., & Wallach, D. A. V. I. D. (1987). Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate. The Journal of Immunology139(4), 1161-1167.

Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G., ... & June, C. H. (1989). CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proceedings of the National Academy of Sciences86(4), 1333-1337.


Availability: In stock

Size Price Qty
1mg
$40.00
5mg
$95.00