LY294002
Catalog Number : 1543664
description
LY294002 is a morpholine-containing potent reversible inhibitor of phosphoinositide 3-kinases (PI3Ks) and BETproteins. It is reported to be promote the differentiation of insulin-producing cells from embryonic cells and inhibit the growth of ovarian carcinomas.
Additional Information
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Applications:
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FA
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Synonyms:
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY-294002
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Formulation:
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Crystalline solid
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Chemical Name:
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2-morpholin-4-yl-8-phenylchromen-4-one
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Molecular Formula:
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C19H17NO3 |
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Molecular Weight: |
307.3
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CAS Number
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154447-36-6
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Gharbi, S., Zvelebil, M., Shuttleworth, S., Hancox, T., Saghir, N., Timms, J., & Waterfield, M. (2007). Exploring the specificity of the PI3K family inhibitor LY294002. Biochem. J, 404, 15-21. Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994). A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). Journal of Biological Chemistry, 269(7), 5241-5248. Sanchezmargalet, V., Goldfine, I. D., Vlahos, C. J., & Sung, C. K. (1994). Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochemical and biophysical research communications,204(2), 446-452 |