JAK Inhibitor I
Catalog Number : 4570371
description
JAK Inhibitor I is a potent and reversible Janus protein tyrosine kinases (JAKs) inhibitor that functions through its interaction with the ATP binding site. It is reported to inhibit the IL-2 and IL-4 dependent proliferation of CTLL cells and to block the phosphorylation of STAT5.
Additional Information
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Applications:
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FA
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Synonyms:
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Pyridone 6, CMP-6, CMP 6
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Formulation:
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Crystalline solid
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Chemical Name:
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2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one
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Molecular Formula:
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C18H16FN3O |
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Molecular Weight: |
309.3
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CAS Number
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457081-03-7
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Efe, J. A., Hilcove, S., Kim, J., Zhou, H., Ouyang, K., Wang, G., ... & Ding, S. (2011). Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nature cell biology, 13(3), 215. Kim, J., Efe, J. A., Zhu, S., Talantova, M., Yuan, X., Wang, S., ... & Ding, S. (2011). Direct reprogramming of mouse fibroblasts to neural progenitors. Proceedings of the National Academy of Sciences, 108(19), 7838-7843. Pedranzini, L., Dechow, T., Berishaj, M., Comenzo, R., Zhou, P., Azare, J., ... & Bromberg, J. (2006). Pyridone 6, a pan-Janus–activated kinase inhibitor, induces growth inhibition of multiple myeloma cells. Cancer research, 66(19), 9714-9721. |