IWP-4
Catalog Number : 6861787
description
IWP-4 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.
Additional Information
|
Applications:
|
FA
|
|
Synonyms:
|
Inhibitor of Wnt Production-4
|
|
Formulation:
|
Crystalline solid
|
|
Chemical Name:
|
N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide
|
|
Molecular Formula:
|
C23H20N4O3S3 |
|
Molecular Weight: |
496.6
|
|
CAS Number
|
686772-17-8
|
|
Purity:
|
≥95%
|
|
Storage Conditions:
|
Product should be kept at -20°C.
|
|
References:
|
Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Hudson, J., Titmarsh, D., Hidalgo, A., Wolvetang, E., & Cooper-White, J. (2011). Primitive cardiac cells from human embryonic stem cells. Stem cells and development, 21(9), 1513-1523. Bilir, B., Kucuk, O., & Moreno, C. S. (2013). Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med, 11(1), 280. |