IWP-3

Grouped product items
Size	Price	Qty
1mg	$40.00
10mg	$225.00

Catalog Number : 6876006

description

IWP-3 is a Wnt pathway inhibitor by inactivating the Porcupine O-acyltransferase which palmitoylates Wnt proteins. It is reported to inhibit embryonic stem cell self-renewal and promote cardiomyocyte differentiation from human stem cells.

Additional Information

Applications:	FA
Synonyms:	Inhibitor of Wnt Production-3
Formulation:	Crystalline solid
Chemical Name:	2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide
Molecular Formula:	C₂₂H₁₇FN₄O₂S₃
Molecular Weight:	484.6
CAS Number	687561-60-0
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nature chemical biology, 5(2), 100-107. Willems, E., Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., ... & Mercola, M. (2011). Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell–derived mesoderm.Circulation research, 109(4), 360-364. Lanier, M., Schade, D., Willems, E., Tsuda, M., Spiering, S., Kalisiak, J., ... & Cashman, J. R. (2012). Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure–activity relationship study based on inhibitors for the Wnt response. Journal of medicinal chemistry, 55(2), 697-708.