Imatinib Mesylate
description
Additional Information
Applications:
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FA
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Synonyms:
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Gleevec, Glivec, imatinib, imatinib methanesulfonate, STI571, STI-571
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Formulation:
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Crystalline solid
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Chemical Name:
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4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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Molecular Formula:
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C29H31N7O CH4SO3 |
Molecular Weight: |
589.7
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CAS Number
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220127-57-1
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., ... & Joensuu, H. (2002). Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. New England Journal of Medicine, 347(7), 472-480. Talpaz, M., Silver, R. T., Druker, B. J., Goldman, J. M., Gambacorti-Passerini, C., Guilhot, F., ... & Sawyers, C. L. (2002). Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood, 99(6), 1928-1937. Gal, H., Pandi, G., Kanner, A. A., Ram, Z., Lithwick-Yanai, G., Amariglio, N., ... & Givol, D. (2008). MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochemical and biophysical research communications, 376(1), 86-90. O'Sullivan, S., Naot, D., Callon, K., Porteous, F., Horne, A., Wattie, D., ... & Grey, A. (2007). Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell‐dependent mechanisms. Journal of Bone and Mineral Research, 22(11), 1679-1689. |