IBMX
Catalog Number : 2885842
description
IBMX is a general inhibitor of cyclic nucleotide phosphodiesterases, increasing the level of intracellular cAMP. It is used to increase cell differentiation, decrease proliferation, and induce apoptosis. IBMX is reported to inhibit TNF-alpha, reduce inflammation, and activate PKA.
Additional Information
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Applications:
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FA
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Synonyms:
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1-Methyl-3-isobutylxanthine, 3-Isobutyl-1-methylxanthine, Isobutyltheophylline
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Formulation:
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Crystalline solid
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Chemical Name:
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1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
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Molecular Formula:
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C10H14N4O2 |
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Molecular Weight: |
222.3
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CAS Number
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28822-58-4
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Usachev, Y., & Verkhratsky, A. (1995). IBMX induces calcium release from intracellular stores in rat sensory neurones. Cell calcium, 17(3), 197-206. Tio, M., Tan, K. H., Lee, W., Wang, T. T., & Udolph, G. (2010). Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One, 5(2), e9398. Hube, F., Lee, Y. M., Röhrig, K., & Hauner, H. (1999). The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect. Hormone and metabolic research= Hormon-und Stoffwechselforschung= Hormones et metabolisme,31(6), 359-362. |