Hydroxyurea
Catalog Number : 1270717
description
Hydroxyurea is a monohydroxyl-substituted urea antimetabolite that exhibits antineoplastic properties by the inhibition of DNA replication and cell proliferation. It inactivates ribonucleotide reductase and induces cell cycle arrest in S-phase. It is reported that hydroxyurea reduces leukocyte adhesion and inhibits the proliferation of human lung cancer cells.
Additional Information
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Applications:
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FA
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Synonyms:
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Hydroxycarbamide, N-Hydroxyurea, Hydrea, Oxyurea
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Formulation:
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Crystalline solid
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Chemical Name:
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hydroxyurea
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Molecular Formula:
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CH4N2O2 |
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Molecular Weight: |
76.1
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CAS Number
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127-07-1
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Yarbro, J. W. (1992, June). Mechanism of action of hydroxyurea. In Seminars in oncology (Vol. 19, No. 3 Suppl 9, pp. 1-10). Young, C. W., & Hodas, S. (1964). Hydroxyurea: inhibitory effect on DNA metabolism. Science, 146(3648), 1172-1174. Elford, H. L. (1968). Effect of hydroxyurea on ribonucleotide reductase. |