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GDC-0068

Catalog Number : 1008962

description

GDC-0068 is a potent and selective pan-AKT inhibitor that targets Akt1, Akt2, and Akt3 over other kinases. It inhibits cell cycle progression and exhibits antitumor properties, reducing the viability of cancer cell lines.

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Additional Information

Applications:	FA
Synonyms:	RG-7440, Ipatasertib
Formulation:	Crystalline solid
Chemical Name:	(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
Molecular Formula:	C₂₄H₃₂CIN₅O₂
Molecular Weight:	458.0
CAS Number	1001264-89-6
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Lin, J., Sampath, D., Nannini, M. A., Lee, B. B., Degtyarev, M., Oeh, J., ... & Lee, L. B. (2013). Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clinical Cancer Research, 19(7), 1760-1772. Yan, Y., Serra, V., Prudkin, L., Scaltriti, M., Murli, S., Rodríguez, O., ... & Wagle, M. C. (2013). Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clinical Cancer Research, 19(24), 6976-6986. Blake, J. F., Xu, R., Bencsik, J. R., Xiao, D., Kallan, N. C., Schlachter, S., ... & Gloor, S. L. (2012). Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of medicinal chemistry, 55(18), 8110-8127.

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