GDC-0068
description
Additional Information
Applications: | FA |
Synonyms: | RG-7440, Ipatasertib |
Formulation: | Crystalline solid |
Chemical Name: | (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one |
Molecular Formula: | C24H32CIN5O2 |
Molecular Weight: | 458.0 |
CAS Number | 1001264-89-6 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Lin, J., Sampath, D., Nannini, M. A., Lee, B. B., Degtyarev, M., Oeh, J., ... & Lee, L. B. (2013). Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clinical Cancer Research, 19(7), 1760-1772. Yan, Y., Serra, V., Prudkin, L., Scaltriti, M., Murli, S., Rodríguez, O., ... & Wagle, M. C. (2013). Evaluation and clinical analyses of downstream targets of the Akt inhibitor GDC-0068. Clinical Cancer Research, 19(24), 6976-6986. Blake, J. F., Xu, R., Bencsik, J. R., Xiao, D., Kallan, N. C., Schlachter, S., ... & Gloor, S. L. (2012). Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors. Journal of medicinal chemistry, 55(18), 8110-8127. |