Gastrin I
Catalog Number : 1003377
description
Gastrin is a peptide hormone that is a major physiological regulator of gastric acid section and a promoter of gastric mucosal growth. It binds to cholecystokinin B receptors (CCKBR) and stimulates an increase in intracellular CA++, the production of inositol phosphate, and the activation of protein kinase C. Gastrin is also involved in gastric epithelial cell proliferation and maturation and is utilized in gastrointestinal organoids research.
Additional Information
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Applications:
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FA
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Synonyms:
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GAS, GAST
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Formulation:
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Crystalline solid
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Chemical Name:
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H-Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
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Molecular Formula:
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C97H124N20O31S |
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Molecular Weight: |
2098.2
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CAS Number
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10047-33-3
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Purity:
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≥95%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., & Roques, B. P. (1999). International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacological Reviews, 51(4), 745-781. Lee, Y., Urbanska, A. M., Hayakawa, Y., Wang, H., Au, A. S., Luna, A. M., ... & Friedman, R. A. (2017). Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus. Oncotarget, 8(1), 203. Fatehullah, A., Tan, S. H., & Barker, N. (2016). Organoids as an in vitro model of human development and disease. Nature cell biology, 18(3), 246. |