Forskolin
Catalog Number : 6652995
description
Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cyclic AMP (cAMP). It has vasodilator and hypotensive properties and can be used to induce neuronal differentiation in stem cells. In combination with other small molecules, it is also reported to be utilized in the chemical reprogramming of embryonic fibroblasts to induced pluripotent stem cells.
Additional Information
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Applications:
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FA
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Synonyms:
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Coleonol, colforsin, NKH-477, NSC 375489
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Formulation:
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Crystalline solid
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Chemical Name:
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[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
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Molecular Formula:
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C22H34O7 |
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Molecular Weight: |
410.5
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CAS Number
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66575-29-9
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Purity:
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≥98%
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Storage Conditions:
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Product should be kept at -20°C.
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References:
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Seamon, K. B., & Daly, J. W. (1980). Forskolin: a unique diterpene activator of cyclic AMP-generating systems. Journal of cyclic nucleotide research, 7(4), 201-224. Laurenza, A., Sutkowski, E. M., & Seamon, K. B. (1989). Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?.Trends in Pharmacological Sciences, 10(11), 442-447. Shamblott, M. J., Axelman, J., Wang, S., Bugg, E. M., Littlefield, J. W., Donovan, P. J., ... & Gearhart, J. D. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proceedings of the National Academy of Sciences, 95(23), 13726-13731. |