Anti-Rat CD28 SAFIRE Purified

Grouped product items
SizePrice Qty
50 ug
$110.00
500 ug
$350.00

Additional JJ319 Formats

Cat.No.FormatStarting From
10313-25SAFIRE Purified$ 110.00
10313-60PE$ 100.00
Catalog Number : 10313-25

description

The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2).

Additional Information

Clone:
JJ319
Format:
SAFIRE Purified
Applications:
FC, FA
Reactivity:
Rat
Isotype:
Mouse IgG1
Research Interest:Adaptive Immunity
Cell Type:T Cells
Application:FC, FA
Clone:JJ319
Preparation:
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
References:

Tacke, M., Clark, G. J., Dallman, M. J., & Hünig, T. (1995). Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester. The Journal of Immunology154(10), 5121-5127.

Tacke, M., Hanke, G., Hanke, T., & Hünig, T. (1997). CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28. European journal of immunology27(1), 239-247.

Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity2(6), 555-559.

 

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