Anti-Mouse/Rat CD40 SAFIRE Purified
Additional HM40-3 Formats
| Cat.No. | Format | Starting From |
|---|---|---|
| 02512-50 | FITC | $ 165.00 |
| 02512-25 | SAFIRE Purified | $ 195.00 |
Catalog Number : 02512-25
description
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
Additional Information
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Clone:
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HM40-3
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Format:
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SAFIRE Purified
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Applications:
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FC, FA
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Reactivity:
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Mouse, Rat
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Isotype:
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Armenian Hamster IgM, kappa
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| Research Interest: | Adaptive Immunity |
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| Cell Type: | B Cells, Dendritic Cells, NK and NKT Cells, Macrophage / Monocyte |
| Application: | FC, FA |
| Clone: | HM40-3 |
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Preparation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., & Shirai, T. (1996). CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus. European journal of immunology, 26(12), 3061-3065. Ferlin, W. G., Severinson, E., Ström, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., & Howard, M. C. (1996). CD40 signaling induces interleukin‐4‐independent IgE switching in vivo. European journal of immunology, 26(12), 2911-2915. Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., & Takemori, T. (1996). Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells. European journal of immunology, 26(7), 1451-1458. |