Anti-Mouse IL-1 alpha SAFIRE Purified

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Additional ALF-161 Formats

Cat.No. Format Starting From
82312-25 SAFIRE Purified $ 310.00
Catalog Number : 82312-25


IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. The ALF-161 monoclonal antibody reacts with the precursor, secreted and membrane-associated forms of mouse IL-1 α. The antibody is reported to be usable as the capture antibody in an ELISA assay and exhibits neutralization properties.

Additional Information

SAFIRE Purified
FA, FC, Neutralization
Armenian Hamster IgG
Research Interest: Adaptive Immunity, Innate Immunity
Cell Type: Macrophage / Monocyte
Application: FA, FC, Neutralization
Clone: ALF-161
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Phosphate-buffered aqueous solution, ph7.2.

Shibuya, K., Robinson, D., Zonin, F., Hartley, S. B., Macatonia, S. E., Somoza, C., ... & O’Garra, A. (1998). IL-1α and TNF-α are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice. The Journal of Immunology160(4), 1708-1716.

Fuhlbrigge, R. C., Sheehan, K. C., Schreiber, R. D., Chaplin, D. D., & Unanue, E. R. (1988). Monoclonal antibodies to murine IL-1 alpha. Production, characterization, and inhibition of membrane-associated IL-1 activity. The Journal of Immunology141(8), 2643-2650.

Beckerman, K. P., Rogers, H. W., Corbett, J. A., Schreiber, R. D., McDaniel, M. L., & Unanue, E. R. (1993). Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes. The Journal of Immunology150(3), 888-895.

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